N-ethylethanaminium bromide
Diethylamine
CAS: 109-89-7
Molecular Formula: C4H11N
N-ethylethanaminium bromide - Names and Identifiers
| Name | Diethylamine |
| Synonyms | detn (C2H5)2NH ai3-24215 Diethamine Diethylamin Dietilamina Diaethylamin Diethylamide Diethylamine Dwuetyloamina N-ethylethanamine N-ethylethanaminium N-ethylethanaminium bromide N-ethylethanaminium chloride |
| CAS | 109-89-7 |
| EINECS | 203-716-3 |
| InChI | InChI=1/C4H11N/c1-3-5-4-2/h5H,3-4H2,1-2H3/p+1 |
| InChIKey | HPNMFZURTQLUMO-UHFFFAOYSA-N |
N-ethylethanaminium bromide - Physico-chemical Properties
| Molecular Formula | C4H11N |
| Molar Mass | 73.14 |
| Density | 0.707 g/mL at 25 °C (lit.) |
| Melting Point | -50 °C (lit.) |
| Boling Point | 55 °C (lit.) |
| Flash Point | −20°F |
| Water Solubility | soluble |
| Solubility | H2O: soluble1M at 20°C, clear, colorless |
| Vapor Presure | 14.14 psi ( 55 °C) |
| Vapor Density | 2.5 (vs air) |
| Appearance | Liquid |
| Color | Clear colorless |
| Odor | Ammoniacal; sharp, fishy. |
| Exposure Limit | NIOSH REL: TWA 10 ppm (30 mg/m3), STEL 25 ppm (75 mg/m3), IDLH 200ppm; OSHA PEL: TWA 25 ppm; ACGIH TLV: TWA 5 ppm, STEL 15 ppm (adopted). |
| Merck | 14,3111 |
| BRN | 605268 |
| pKa | 11.02(at 40℃) |
| PH | 13 (100g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Highly flammable. Incompatible with strong oxidizing agents. |
| Sensitive | Air Sensitive |
| Explosive Limit | 2.0-11.8%(V) |
| Refractive Index | n20/D 1.385(lit.) |
| Physical and Chemical Properties | Colorless, volatile flammable liquid, strong ammonia odor. melting point -49.8 ℃ boiling point 55.9 ℃ relative density 0.7056 refractive index 1.3823 BR> flash point -23 ℃ solubility and water, ethanol, ether and other organic solvents are miscible. |
| Use | It is used as an intermediate of medicine, pesticide and rubber accelerator |
N-ethylethanaminium bromide - Risk and Safety
| Risk Codes | R11 - Highly Flammable R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R35 - Causes severe burns |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S29 - Do not empty into drains. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S3 - Keep in a cool place. |
| UN IDs | UN 1154 3/PG 2 |
| WGK Germany | 1 |
| RTECS | HZ8750000 |
| FLUKA BRAND F CODES | 10-23 |
| TSCA | Yes |
| HS Code | 29211990 |
| Hazard Class | 3 |
| Packing Group | II |
| Toxicity | LD50 orally in rats: 540 mg/kg (Smyth) |
N-ethylethanaminium bromide - Upstream Downstream Industry
N-ethylethanaminium bromide - Nature
Open Data Verified Data
colorless volatile flammable liquid, strong ammonia odor. Spontaneous ignition point 254.4 ℃; Explosion limit of 1.8% ~ 10.1%. With water; Ethanol, ether and other organic solvents miscible. Reaction with inorganic acids to form salts, reaction with carboxylic acids; Carboxylic acid esters and anhydrides to form the corresponding amides. Its vapor and air can form an explosive mixture. It is easy to cause combustion in case of high heat, open flame and strong oxidant. It is corrosive and can corrode glass.
Last Update：2024-01-02 23:10:35
N-ethylethanaminium bromide - Preparation Method
Open Data Verified Data
ethanol atmospheric pressure gas phase catalytic method, the reaction can be monoethylamine, diethylamine, triethylamine, ethanol and other mixed liquid, and then through crude distillation, distillation, collecting diethylamine fraction. Or ethyl chloride and ammonia (ammonia) in calcium hydroxide aqueous solution at a certain temperature and pressure reaction, and finally by distillation, distillation can be.
Last Update：2022-01-01 09:27:18
N-ethylethanaminium bromide - Use
Open Data Verified Data
diethylamine as solvent and chemical raw material intermediates, can be prepared procaine, chloroquine, nikethamide, kramine and sulfanilamide and other drugs, can also be used for the production of pesticides, dyes, rubber vulcanization accelerator, mineral processing agents, Textile Auxiliaries, fungicides, corrosion inhibitors, polymerization inhibitors and anti-freezing agents.
Last Update：2022-01-01 09:27:19
N-ethylethanaminium bromide - Safety
Open Data Verified Data
rat oral LD50: 540mg/kg; Rabbit percutaneous LD50:820mg/kg. The product is highly irritating and corrosive. Vapor to the eye irritation, can cause corneal edema. Inhalation of its vapor or mist, can cause laryngeal edema, bronchitis, chemical Pneumonia, pulmonary edema, high concentrations of inhalation can be fatal.
Last Update：2022-01-01 09:27:20
N-ethylethanaminium bromide - Reference Information
| pH range of acid-base indicator discoloration | Strong alkaline |
| relative polarity | 0.145 |
| olfactory Threshold | 0.048ppm |
| Henry's Law Constant | 2.56(x 10-5 atm?m3/mol) at 25 °C (Christie and Crisp, 1967) |
| LogP | 0.58 at 20℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| uses | used as analytical reagents and preservatives, also used in organic synthesis and the manufacture of dyes diethylamine is a pesticide, the intermediate of pyrimidine and herbicide grass Dan, diphenoxamine. diethylamine is a solvent and chemical raw material intermediate, which can be used to prepare procaine, chloroquine, nikethamide, chloramine, sulfanilamide and other drugs, and can also be used to produce pesticides, dyes, rubber vulcanization accelerators, mineral processing agents (sulfur and nitrogen 9), Textile Auxiliaries, fungicides, corrosion inhibitors, polymerization inhibitors and anti-freezing agents. The consumption of diethylamine and diethylamine: cefazolin sodium 0.789/kg, cefradine 0.059/kg, berberine 0.030/kg, sulfadiazine 0.150/kg, chloroquine phosphate 0.340/kg, kebiqing 0.710/kg, embutramine 0.960/kg, haemostasis 0.660/kg, procaine hydrochloride 0.600/kg, lidocaine hydrochloride 0.890/kg. used as intermediates of medicine and pesticide and rubber accelerator used in organic synthesis and curing agent of epoxy resin determination of antimony, platinum and tin, determination of carbon disulfide and magnesium, organic synthesis. Diethylamine is a solvent and chemical raw material intermediate, can be used to prepare procaine, chloroquine, nikethamide, kramine and sulfanilamide and other drugs, can also be used in the production of pesticides, dyes, rubber vulcanization accelerator, mineral processing agent (sulfur and nitrogen 9); Textile Auxiliaries, fungicides, corrosion inhibitors, polymerization inhibitors and anti-freezing agents. |
| production method | 1. Ethanol atmospheric pressure gas-phase catalytic method gas-phase ethanol, ammonia and hydrogen are mixed at 1:0.8:1.5(mol), and through preheating (170-180 ℃) into the first reactor equipped with copper-nickel catalyst, the vapor-phase catalytic reaction was carried out at 195 ° C. To 200 ° C., and then the reaction was carried out in a second reactor having a copper-nickel catalyst, followed by synthesis reaction, and reduction was carried out at 170 ° C. To remove impurities such as acetonitrile. The reaction gas is condensed to obtain a mixture of one, two, triethylamine, ethanol and the like, and then subjected to crude distillation, rectification, and cut out 54-57 ℃ distillate to obtain diethylamine product. Its content can reach more than 95%, while a small amount of triethylamine. 2. Ethyl chloride and ammonia (ammonia) in calcium hydroxide aqueous solution, at a pressure of 2.26MPa, a temperature of about 135 ℃ reaction for 6h, and then add sodium hydroxide to destroy the formation of diethylamine calcium chloride double salt, and finally by distillation, rectification, the 55-57 ° C cut fraction is the diethylamine product, the content is more than 98%, the yield is 80%, and a small amount of triethylamine can be obtained at the same time. 3. Acetonitrile hydrogenation and ammoniation method. 4. Hydrogenation and Amination of acetaldehyde. 5. Diethylaniline method. The preparation method is to use a mixture of ethanol, ammonia and hydrogen, after preheating, the temperature is about 180, Under the action of nickel-copper catalyst, the first converter (temperature about 200 ℃) and the second converter (temperature about 80 ℃) are successively used for synthesis reaction, and the reaction products are subjected to crude distillation, the finished product was obtained by distillation. |
| category | flammable liquid |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50: 540 mg/kg; Oral-mouse LD50: 500 mg/kg |
| stimulation data | Skin-rabbits 100 mg/24 h moderate; eye-rabbit 50 μg severe |
| explosive hazard characteristics | explosive when mixed with air |
| flammability hazard characteristics | in case of fire, high temperature, oxidant flammable; toxic NOx smoke from combustion |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Stored separately from oxidants and acids |
| fire extinguishing agent | dry powder, water mist, carbon dioxide, foam |
| Occupational Standard | TWA 30 mg/m3; Tel 75 mg/m3 |
| spontaneous combustion temperature | 594 ° F. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
| immediate life-and health-threatening concentration | 200 ppm |
Last Update：2024-04-09 15:16:45
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Raw Materials for N-ethylethanaminium bromide
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